BackgroundCardio-vascular disease and depression are thought to be closely related, due to shared risk factors.The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus laguna 3hp dust collector trial.Methods and findingsParticipants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR).The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years.
The association between CVR and depressive status klaire labs ashwagandha at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models).HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.
50)].MR and HR participants with total cholesterol ConclusionsImproving cardiovascular health could prevent the onset of depression in the elderly.Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.International Standard Randomized Controlled Trial (ISRCTN89898870).